Less Serotonin Means Depression for Women and Impulsiveness for Men

Sep 18, 2007

Apparently both men and women have different reactions to the same biochemical manipulation. One of the most spread and most studied mental disorders is considered to be major depressive disorder (MDD).

The fact that reduced serotonin transmission is the cause of functional changes linked to major depressive disorder is already known. Most antidepressants produced today are able to block the uptake site of serotonin in human's brain.

Recent study published in Biological Psychiatry focuses on significant changes in sex and genes what concerns the way both men and women respond to decrease in serotonin function, especially regarding mood and impulsivity of both genders.

Together with his colleagues, Dr. Espen Walderhaug, one of the authors of the research, used a special technique on healthy patients. The technique is entitled acute tryptophan depletion. It is meant to decrease the levels of serotonin in the brain. Researchers found that men turned out to be more impulsive; however, they did not experience any changes in their mood.

Apart from men, researchers found that women had a worsened mood, they becoming more cautious. Such reaction is often linked to depression. Scientists also found that the effect of mood worsening in women was powered by deviation in the promoter region of 5-HTTLPR, which is a serotonin gene, known as transporter.

What researchers have found outlines the complexity of both studying and treating these issues. Dr. Walderhaug stated that the findings of the research performed by his team "might be relevant in understanding why women show a higher prevalence of mood and anxiety disorders compared to men, while men show a higher prevalence of alcoholism, ADHD and impulse control disorders."

Healthy Life Spot


Oct 27, 2015 09:57 PM » posted by: Rahul
I've had recurrent drisesepon for decades, sometimes lasting a month or two, sometimes a year or more. The worst for me is how much my drisesepon hurts on the inside, how much it makes me loathe and hate myself -- but that's the drisesepon screwing up the chemicals, the neurotransmitters, in my brain and telling me lies. It really makes me feel hopeless, though, makes me beat myself in the head. The most recent episode, Depression led me to go shopping for a weapon because I just didn't think I could hold on any longer. I decided to go into the hospital because I knew I would die if I didn't. This was last year, after 3 years of worsening drisesepon, despite meds and therapy and all. I'm healthy now. though, and glad I'm alive. It is, indeed, crucial to remember that you will feel better someday and that the negative messages your brain tells you are NOT true. And to keep asking for help when things are bad. Was this answer helpful? http://exbhrkvrru.com [url=http://xrwgozqlusg.com]xrwgozqlusg[/url] [link=http://syztxxj.com]syztxxj[/link]

Oct 26, 2015 12:30 PM » posted by: Zailuthfi
Hey I am going to try and answer your quesitons in the same order you asked them..MILD DEPRESSION:Because this is only the mild form of the disorder, the symptoms are not very severe. Sufferer may carry on with their normal lives, only appearing low in spirits and possibly less sharp in their thinking or in their interest. They may stop doing things they do not actually have to do, but will often continue with the essentials, such as going to work or carring for the family. However, they will tend not to be as conscientious about these things as previously, or will become upset because they feel they are not coping as well as they should because they feel too tired. SEVERE DEPRESSION:Severe Depression includes markedly depressed mood complicated by symptoms such as slowed speech, slowed (or agitated) responses, markedly impaired memory and concentration, excessive (or diminished) sleep, significant weight loss (or weight gain), intense feelings of worthlessness and guilt, recurrent thoughts of suicide, and lack of interest in pleasurable activities. This form of clinical depression is a dangerous and excruciating illness. The emotional structure of the brain has frozen into a pattern of misery that cannot be altered by willpower, a change of scenery, or the most earnest efforts of friends. In a sense, the brain has locked up like a crashed computer.BI - POLARPeople with Bipolar Disorder experience extreme mood swings that can take three different forms: manic, depressive, and mixed episodes. Symptoms can include both a lowering of mood (depression) and an exaggerated elevation of mood (mania). MANIC BI POLAR EPISODESIn a manic episode, some people with Bipolar Disorder may experience an elevated (extremely happy) mood, often described as feeling "on top of the world." Others may feel very agitated and act uncooperative and aggressive, which can be frightening for themselves and others. Patients often report that these episodes result in consequences that must be dealt with after the symptoms fade.A diagnosis for a manic episode includes either an elevated or an irritable mood lasting at least a week plus three or more of the following symptoms: •Talking too fast or too much•Risky or impulsive behavior, like sexual promiscuity or excessive spending sprees•Needing little sleep•Being easily distracted (your attention shifts between many topics in just a few minutes)•Having an inflated feeling of power, greatness, or importance•Intense focus on goal-directed activity•Racing thoughtsDEPRESSIVE BI - POLARA diagnosis for a major depressive episode requires having a depressed mood or loss of interest or pleasure in activities a person used to enjoy. In addition, four of the following symptoms must also be present nearly every day for at least two weeks: •Significant weight loss when not dieting or weight gain (i.e., a change of more than 5% of body weight in a month), or decrease or increase in appetite•Insomnia or hypersomnia (excessive sleeping) nearly every day•Feeling restless or sluggish to the point that others notice•Fatigue or loss of energy•Feelings of worthlessness or excessive or inappropriate guilt•Diminished ability to think or concentrate, or indecisiveness•Recurrent thoughts of death (not just fear of dying), recurrent suicidal thoughts without a specific plan, or a suicide attempt or a specific plan for committing suicideMixed episodesA mixed episode includes symptoms that are both manic and depressive. ABILIFY (aripiprazole) is used for the treatment of manic or mixed episodes associated with Bipolar I Disorder in adults and in pediatric patients 10 to 17 years of age.Bipolar is verry different from clinical depression Was this answer helpful?

Nov 18, 2010 09:11 PM » posted by: Major Depressive Disorder
A major depressive disorder is one of the major mood disorders were diagnosed in the United States, affecting more than 20 million American adults per year or age 18, and the use of some degree. Although the frequency, the 20 million people is less than 10 percent of the population. Many people who can fight with their symptoms of depression is difficult to understand, while the corresponding.

Sep 26, 2007 09:26 PM » posted by: Ann
Basically, serotonin is related to regulation of aggression, body temperature, mood, sleep, vomiting, sexuality, and appetite.It also acts like antidepressant. There are also products that contribute to the release of serotonin like chocolate but the effect would be rather short.

Sep 21, 2007 10:41 AM » posted by: mark anthony
Just want to ask questions about serotonin.So, what is the use or major role of serotonin in our body?if i have lack of it,what are the problem associated behind that?theirs any activity that could increase and decrease serotonin?

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