The previous studies conducted by Professor Siobhan Quenby, of School of Reproductive and Developmental Medicine, at the Liverpool University, showed that women, who underwent numerous miscarriages in the past have a high level of the uterine Natural Killer immune cells.
The findings of the study of 120 pregnant women with an increased risk of miscarriage suggested that in almost half of the cases, women had high levels of these immune cells. This resulted in high oxygen level in the uterus during the early stage of the pregnancy, which is an unfavorable condition for implantation of the embryo.
Researchers have developed a medication that was aimed at regulating the immune response in pregnant women to lower the risk of miscarriage. The pill should be taken once a month for a three months period. Prednisolone drug contains a steroid that is often used in treatment of asthma and allergies. The only side effects revealed so far are the increased appetite and mood fluctuations.
The initial trials of the Prednisolone were quite successful, but further trials are needed to exclude the placebo effect. The trials showed that 30 out of 40 women who had frequent miscarriages in the past gave birth to the babies. One of these women is known to have 22 miscarriages, according to Quenby.
The researchers say that the pill will be helpful to a great number of women who underwent through unexplained miscarriages.